Expression of Macrophage Migration Inhibitory Factor in Acute Ischemic Myocardial Injury

Macrophage migration inhibitory factor in myocardial ischaemia/reperfusion injury.

Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI. Cardioprotection by MIF is likely to be a multifactorial phenomenon mediated by receptor-mediated signalling processes, intracellular protein-protein interactions, and enzymatic ...

I-43: Expression Profile of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway as A Potentional Biomarker in Pathophysiology of Endometriosis

Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...

Macrophage Migration Inhibitory Factor

The expression of macrophage migration inhibitory factor in adenomyosis

The aim of the present study was to investigate whether the expression of macrophage migration inhibitory factor (MIF) is altered in eutopic endometrium and ectopic lesion of women with adenomyosis. MIF expression was assessed by immunohistochemistry, western blotting analysis. Elevated expression of MIF protein was seen in eutopic endometrium and ectopic lesion of women with adenomyosis (P<0.0...

Upregulation of macrophage migration inhibitory factor gene expression in stroke.

BACKGROUND AND PURPOSE MIF has been implicated to function in many inflammatory processes. This study examined whether MIF expression was affected in stroke and its underlying molecular mechanism. METHODS ELISA and qRT-PCR were used to detect MIF protein and mRNA in PBMCs from stroke patients, the ischemic rat brains, and controls. A MIF promoter assay under hypoxia was performed. RESULTS M...